ACTualize-UFH, what is it?
ACTualize is an interactive tool dedicated to estimating the individual pharmacodynamics of unfractionated heparin (UFH) in cardiac surgery using a Bayesian approach with activated clotting time (ACT) measurements
This tool offers the possibility to estimate individual pharmacodynamic parameters and provides dosing regimen proposals
Disclaimer: This website and application are intended for research and informational purposes only.
We do not assume any responsibility for how the content, services, or tools provided on this site are used.
Any unauthorized or improper use of this application is the sole responsibility of the user.
We disclaim any liability for damages, losses, or issues arising from misuse or unintended use.
Last Updates
Version 0.1.2 - February 2, 2025
New features:
- Algorithm Enhancements:
- Expanded functionality to support the use of the application outside of cardiopulmonary bypass (CPB) surgery.
- Improved ACT prediction and UFH recommendation by incorporating CPB start time into the algorithm.
- Others:
- Protamine Administration Prediction: Now estimates protamine dosage at the end of surgery based on total UFH administered (bolus and infusion), with customizable protamine-to-UFH ratio settings.
- Added a non-blocking warning when attempting to calculate a new UFH dosing recommendation without a new ACT measurement.
- Added a blocking warning when calculating a new UFH dosing recommendation under CPB if the start date and time for the CPB have not been set.
- Improved calendar visibility and UI
Bug fixes:
- Mobile Compatibility
- Drag-and-drop functionality for ACT measurements, heparin bolus injections, and heparin infusions is now fully functional on iOS and Android.
- UI & Usability:
- Browser auto-translation should no longer alters drug unit displays.
Known issues:
- On mobile devices, there are still issues with scrolling when interacting with the drag-and-drop sections.